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KMID : 0351219950270050485
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Korean Journal of Infectious Diseases
1995 Volume.27 No. 5 p.485 ~ p.492
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Effect of Ciclopirox 8% Nail Lacquer in Onychomycosis-Twice Weekly Method
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Abstract
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Background:
@EN Although newer oral antifungal agents have been developed with decreased hepatotoxicity and increased officacy, there are still sighnificant incidences of hepatotoxicity, gastrointestinal problem, and many drug interactions which limit their
clinical use. Furthermore, they need to be administered for at least 3 to 6 months in the treatment of onychomycosis. Ciclopirox 8% nail lacquer is a newly developed local antifungal agent with excellent nail penetration ability and broad
fungicidal and
fungistatic effects. We evaluated the therapeutic effect of ciclopirox 8% nail lacquer in onychomycosis.
@ES Methods:
@ES Therapeutic effect of ciclpirox 8% nail lacquer was studied in 18 patients with distal subungal or white superficial onychomycosis of toe nails. The nail lacquer was applied once daily for the first month. and then twice weekly for the next
five
months to the affected nails. Direct KOH smear and fungus culture were performed before and after the therapy. The affected area in the target nail was measured monthly.
@ES Results:
@EN The area ratio of the lesion in the target nail decreased significantly from 29.2%to 11.5% at the end of the study(p<0.001). Significant improvement was also seen in the 5 patients in whom the involved area was 50% or moro in the target
nail(p<0.001). The mycoloGICAL CURE RATE WAS 33%. Compiete cure or improvement was noted in 01.1% by the investigator's evaluation and in 89% by the patients' subjective assessment The tolerance and cosmetic acceptance were excellent. Mild
periungal
erythema with or without pain and ingrowing nail was reported in 3 patients(16.7%).
@ES Conclusion:
@EN Ciclopirox 8% nail lacquer can be used as an effective local agent in the treatment of distal subungal and white superficial onychomycosis, even in more severe cases.
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KEYWORD
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